Jesse then went to another bar, where his requested a band to play "A Walk to the Peak". Cassidy asked Jesse what he is planning to do on the Eugene situation. Eventually, a Jesse followed Featherstone back to her apartment, where Featherstone explained how she heard of God leaving heaven. When his soul merged with the angel-demon entity Genesis, her powers were focused into what Jesse Custer would refer to as "The Word of God." Shortly after this, Jesse learned the Grail had found God at the Alamo. During which, Jesse and Tulip ding Odin. Later, in the kitchen, Cassidy approached him about Eugene. After which, Jesse hid the Saint of Killers weapons beneath Denis' flat.Jesse, Cassidy, and Tulip wrap up looking through every jazz club in New Orleans but come out short. Cassidy joined him soon after but Jesse asked why he should trust him after keeping Tulip's secret past from him. DeBlanc and Fiore decided to leave and go for the other option, causing Jesse to plead, telling them he didn't know why that happened.Jesse sat against his church as Odin's men began their siege. The Saint warned him he'd be sending his own soul to Hell and Jesse settled on drowning the Saint in the swamps of Angelville instead. Tulip reluctantly agreed and they headed for the chapel. The two left Jesse. Odin then told Jesse that he had been the least successful out of him and his predecessors. The last panels show Cassidy, now human after his deal with God, watching the sunset and talking to himself, or rather out to Jesse, saying that he will try to act like a man. Jesse called the congregants all sinners, but it wasn't too late.
Jesse left and commanded the secretaries to let him out but Genesis faltered a couple times before working.Jesse pondered over God's "man-dog" couch before returning to Denis' flat. Jesse prefers to keep his Word in reserve, using it only when he has to. Jesse was told that Tulip was right that he is still the same person he once was. Jesse apologized for letting him burn. The two set Carlos free and handed him a tire iron and a gun. Jesse thanked Emily and Tulip for helping out with everything. Moments after, Jesse returned to Starr's office and asked what's next. The two told spoke that they saw the worst in each other. Jesse revealed that God is missing, though Fiore didn't care.
The two then beat him senseless.Jesse took his place on the pulpit, though Odin interrupted him. Tulip intervened, stopping the Saint from killing him but shortly after, Jesse stops the Saint from killing Tulip. Jesse told the two that if God needed their help, they'll help him, and if he doesn't, they would kick his a**. Despite that, Cassidy told Jesse that Eugene doesn't deserve to be condemned to Hell. Jesse was then driven away by Hugo Root as the townsfolk begged him to save them, for they are all sinners.While being driven to the sheriff station by Hugo, Jesse told Hugo he sent Eugene to Hell. Later, Jesse apologized to Tulip and agreed to do anything for her. His skills allow him to easily beat the superhumanly strong and fast vampire, Cassidy (at least until Cassidy sucker-punches him). Jesse asked questions on Genesis, including why Genesis didn't make him explode. Jesse was told by Eugene that he felt guilty and believed he shouldn't be forgiven.
Jesse was told to hide under the bed. The two engage in an altercation. Jesse, Cassidy, and Tulip returned to Masada, though the three were split up. When Jesse learned more about his powers, Jesse became arrogant.
There, Jesse insisted they continue regardless if they are being followed. Jesse was a cocky young man, using his skills and good looks to get easy money. Jesse told them he would bring each one of them back to God one by one. Jesse and Cassidy have drinks on the balcony as Cassidy continued to share foreskin conspiracies. However, both of them realized it would never work out, as Jesse was still in love with Tulip. After Tulip left, Jesse called Emily stupid when she told him that she believed in him the moment she saw him.
Jesse told the two he knows where God is but the two shut him down and left Jesse to find God alone.